Alpha-Thalassemia is blood disorder that reduces the production of hemoglobin, leading to a lack of oxygen to many parts of the body. People affected with this condition also have a shortage of red blood cells (anemia). There are two types: Hb Bart syndrome and HbH disease. Hb Bart is usually fatal to the fetus or newborn; HbH can be managed by blood transfusions if necessary, although many HbH patients require no treatment. Hb Bart: Usually fatal in childhood, physical impairment. HbH: May have some impact on lifespan. Possible physical impairment. Treatment available.

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