Ashkenazi Jewish Genetic Diseases: 19 Disease Panel

Ashkenazi Jewish Genetic Diseases: 38 Disease Panel

Sephardic/Mizrahi Jewish Genetic Diseases

Alpha-Thalassemia

Alpha-Thalassemia

A blood disorder that affects the production of the alpha protein in hemoglobin leading to anemia and insufficient supply of oxygen throughout the body. There are two types of the disease: Hb Bart syndrome (more serious) is usually fatal to the fetus or newborn and HbH (less serious) can be managed by blood transfusions if necessary. Many HbH patients require no treatment. Screening is done by a complete blood count (CBC) followed by DNA analysis if warranted.

Carrier Frequency: 1 in 5 to 1 in 100 Moroccan Jews, 1 in 4 to 1 in 13 Yemeni Jews, 1 in 7 to 1 in 40 Iraqi Jews, 1 in 80 Kurdish Jews

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