Megalencephalic Leukoencephalopathy with Subcortical Cysts

Megalencephalic Leukoencephalopathy with Subcortical Cysts [MLC1]: A leukodystrophy characterized by early-onset macrocephaly and delayed-onset neurologic deterioration, including cerebellar ataxia, spasticity, epilepsy, and mild cognitive decline.

Sephardic-Mizrahi Jewish Carrier Frequency: 1 in 40