Fanconi Anemia-Group A

Fanconi Anemia, Group A [FANCA]: A disorder characterized by developmental abnormalities in major organ systems, early-onset bone marrow failure, and a high predisposition to cancer. The cellular hallmark of FA is hypersensitivity to DNA crosslinking agents and high frequency of chromosomal aberrations pointing to a defect in DNA repair.

Sephardic-Mizrahi Jewish Carrier Frequency: 1 in 133